Outlook Anywhere 2 Factor Authentication

Hello, since there is no native support for 2FA by Outlook Anywhere I'm wondering if it's possible to set up 2FA with SAML. For example, Outlook is connecting and authenticated by the NTLM Auth object. After this AD query finds users mobile number from AD, SAML is triggered and a iRule sends a SMS with a "magic link". The user has to open this link on his smartphone and the session is allowed. The link refers to the BigIP as SAML service provider. Something like Ping Identity does without external service provider and mobile app where you have to confirm your ID by sliding over. What do you think? Is this possible or have someone did a scenario like this already?

Cheers