Forum Discussion
I haven't tried it myself, but you have the option under Client Settings to use "DNS Address Space" (I'm using v. 16.1).
You are talking about split tunnel from what I understand and split tunnel based on FQDN and not ip address (on your computer this will be seen ip routes that send specific traffic to the tunnel interface). The short answer is yes as this has been availabe in F5 APM for a long time. Look at the links below:
https://support.f5.com/csp/article/K55104964
https://support.f5.com/csp/article/K03430467
https://support.f5.com/csp/article/K49720803#link_07