iRule for non http services

ndubey2 You are 100% positive that the virtual server is being hit? It shouldn't matter if it's browser based or application based, the only thing that really matters is the protocol being used for the application to function. Your best bet is to first confirm that your traffic is indeed hitting the virtual server in question. You should be able to run the following tcpdump which will save to a file located in directory "/shared/tmp/" and is named "mycap.pcap" which can be exported and opened in wireshark.

tcpdump -nni 0.0:nnp host <VS_IP> -w /shared/tmp/mycap.pcap

If for some reason after this you see traffic hitting the virtual server in question referencing the F5 information saved in each packet you will then want to confirm that it is indeed HTTP traffic. If this isn't HTTP traffic then your iRule will not work. If this is going over HTTPS you will want to ensure that you are performing SSL termination on the F5 in order for it to look at the HTTP header.