BigIp and Keep-Alive feature

Hmmm, not sure this is possible in any simple way. You should be able to disable the HTTP Pipelining & Persistent Connections features in the HTTP profile assigned to the VS but I suspect this will only apply client-side. That being said, if Keep Alives are not seen/allowed client side perhaps the logic is setup so that such features are not used server side. I'd try it and then test.

If it doesn't work we'd be looking at an iRule to remove the Keep Alive header from server side requests as they leave the device.