This message indicates that the SSL version or the Cipher list supported by the F5 and its peer (the client) doesn't match.
You should do a tcpdump on the client or on the F5 system to check the ssl handshake. You may see that there is no matching ciphers between the browser and the VS.
If there are any doubts on the procedure of how to renew existing SSL certificates and keys, there's a video that got you covered: https://youtu.be/WU3C8W25vvE
It turned out that the F5-hosted website had some existing configurations in a Palo Alto firewall. (i.e. an SSL certificate, and a decryption rule)
Browsing the website finally worked, after I used its new SSL certificate to update the relevant configurations in both the Palo Alto firewall and the F5 load balancer.
This issue usually involves a problem with your web browser or your site’s SSL certificate. The browser’s telling you that because it’s trying to tell you there’s a problem with the certificate the website is using for HTTPS, so “this site can't provide a secure connection”. In all cases the end-to-end encryption is still going to work just because HTTPS can’t function without it. There is no definite guide for managing this error.
Two possible options to get rid of this issue
Use Self Sign certificate
Remove domain security policy:
Steps for Chrome :
Go to : chrome://net-internals/#hsts
Query HSTS/PKP domain for localhost
Use Delete domain security policies option to delete configuration for localhost
