Redirect Rewrite not working - how write an irule to redirect non-standard port

Well, enough digging and I guess you can answer your own question.

I found that a stream profile was needed, I presume b/c it wasn't actually a redirect but I'm not entirely certain. With that said, I applied an empty stream profile and the following irule:

when HTTP_REQUEST {
     tell server not to compress response
    HTTP::header remove Accept-Encoding

     disable STREAM for request flow
    STREAM::disable
}
when HTTP_RESPONSE {
     catch and replace redirect headers
    if { [HTTP::header exists Location] } {
        HTTP::header replace Location [string map {"http://" "https://"} [HTTP::header 
Location]]
    }

     only look at text data
    if {[HTTP::header "Host"] contains "10108" }  { } {

         create a STREAM expression to replace any http:// with https://
        STREAM::expression {@http://example.com:10108@https://example.com@}

         enable STREAM
        STREAM::enable
    }
}

...and it works like a champ.