Problem with servers using F5 as DG

mmm it's somehow general the information. Try adding and Snat automap in the advanced config of the VS just for testing. Snat also helps with some routing problems . Seems like some broken sessions are ocurring there.

Also,it's kinda odd that the server issues a request to VS IP address, and because a lb decision, the f5 fwd the packet to the same server again.

Try tcpdump on internal and external interfacesk, and would be nice to run also wireshark on the proper server in order to know where packet is getting stucked.

Good Luck,

HHeredia