Issue with app pushing F5 LTM out of the way!!! HELP

It sounds like the application may be at some point in the transaction sending a redirect to the client that references the hostname of the server instead of whatever FQDN is being used to access the virtual server on the LTM. You can use stream profiles on the LTM to change the redirects going back to the client if you know what the redirect is coming back from the server. You'd probably have to grab a packet capture on the LTM to determine this, and then build an iRule using a stream profile, like is explained here:

http://support.f5.com/kb/en-us/solutions/public/8000/100/sol8115.html