HTTP Profile breaking HTTPS site

Think of the various profiles (TCP, HTTP, etc.) as "filters". When you want to evaluate HTTP traffic (as in use the HTTP events and commands), you need to apply an HTTP profile. When you want to evaluate TCP traffic, you apply a TCP profile. When you want to evaluate SSL events, you apply SSL profiles, and so forth for other protocols. iRules are actually global to the stack (layer 4 - 7). The events and commands you can use, however, are dependent on the filters you apply.