Guidelines for pointing to one web server with many Virtual Sites

That's kinda what I was thinking, that basically the BigIP will just flow traffic as normal with one VS, but our architecture typically (for logical reasons) separates on a one-to-one basis of BigIP Virtual Server to each individual instance on the web server. I just wasn't sure if this is standard, best practice, etc? Perhaps it would be better to go and create a unique port for each site and make a VS on the BigIP to each port...?