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BIG-IP SSL vulnerability CVE-2017-6168
RSA is the oldest most widely supported SSL/TLS key exchange. If you disable it, very old clients will not be able to handshake. The main one would be IE on XP.
When considering changing client SSL profile configuration, a good way to get an idea of how client will be affected is to use a test virtual server, and then test with Qualys SSL Labs server test: https://www.ssllabs.com/ssltest/
In the report, look for the "Handshake simulation" section. This reports the cipher used for a selection of browser and OS versions and any errors/warnings.
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