Hey Ryan,
The boxes for the Tunneling should be all unchecked when using APM, could you try unchecking all of the boxes and try again?
Just out of curiosity as well, your locked.properties file, are you using a lot of mixed clients? just trying to understand why you have all of those protocols enabled...
Also if you didnt know F5 and VMware have collaborated to showing this kind of configuration in a lab environment, these configurations might be useful to your implementation.
HOL-MBL-1759 Module 3 for APM and PCoIP Proxy
http://labs.hol.vmware.com/HOL/catalogs/lab/2792
Also you can just goto the manual section as per this link
http://docs.hol.vmware.com/HOL-2017/hol-1759-use-3_html_en/l531442