Looks like VMware has an article that states "Blast Extreme also works over TCP port 443 and UDP port 443 and delivers a secure user experience leveraging SSL technology".
Not sure what this means on the F5 side of things, as it also states "The “Poor” setting uses UDP networking for control, broker and protocol traffic. To use this setting, IT administrators must deploy VMware Unified Access Gateway".
I think we're going to try configuring this next week and see what transpires. Might be as easy as setting-up the UDP/443 listener and assigning the VDI profile.