Webtops for Portal Access. Remove home tab.

Yes, this is posible. The procedure is described here:

https://support.f5.com/csp/article/K15271

Don't forget to apply the policy after updating this setting. It may be needed to clear the webacceleration cache if you are using this. Use 'tmsh delete /ltm profile ramcache <profilename>' to clear the ramcache entries.