Web Directory based routing on F5 Big IP

You can do this with a local traffic policy, or (less efficient) an irule, attached to the VS. The irule would use HTTP::uri, coupled with the "pool" command. If you set a default pool for the VS, then all you need your rule to do is detect exceptions, and over-ride the default with your other pool.

Here's what a policy would look like if you didn't set a default pool: