I actually ran into this question during the week. I have heard cautious words of using it but there is an official statement from F5 which you can find in the release notes of version 12.0 stating the following:
Certain hypervisors support a snapshot of the virtual machine taken with the active state of the memory. On VMware, this temporarily freezes the virtual machine. This might produce undesired results. Taking a snapshot of the virtual machine's memory on VMware. Pauses the virtual machine, which might produce undesired results. Workaround: To avoid this problem on VMware hypervisors, do not include the virtual machine's memory when taking snapshots. On VMware, uncheck the option: Snapshot the virtual machine's memory.
In other words, it should be fine as long as you do not take a snapshot of the virtual machines memory. Or perhaps even turn off the machine and perform the snapshot.