You'll have to reply with additional details on what the problem is.
If you're talking about the command
# lsof -ws | grep -i 'size\|deleted'
then you would need to restart the noted daemon (Command) to release the deleted files, or reboot.
Be cautious though, restarting services can cause an outage depending on the service. For example: restart httpd is safe and can be done during production hours, restarting TMM would cause a complete outage.