I want to enable APM policy that will route my company domain traffic( for e.g. site.company.com, app.company.com etc) instead of putting static IPs in the LAN address space? This way, I don't need to maintain all company public application IPs in the VPN settings.
You are talking about split tunnel from what I understand and split tunnel based on FQDN and not ip address (on your computer this will be seen ip routes that send specific traffic to the tunnel interface). The short answer is yes as this has been availabe in F5 APM for a long time. Look at the links below: