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Hi Kuldeep22,

sure, you can do this with iRules:

when HTTP_REQUEST priority 500 {
    if { [HTTP::cookie exists "Name_of_your_Cookie"] } {
        ASM::disable
        pool name_of_your_pool
    } else {
        ASM::enable "/Common/name_of_your_ASM_policy"
        pool name_of_your_other_pool
    }
    
}

This iRule will check if a cookie with the name Name_of_your_Cookie exists. If yes, it will disable ASM and assign a pool. If no, it will enable a specific ASM policy and assign a different pool.
Of course this is just a suggestion, with iRules the sky is the limit for such use cases.

Probably you can also do this with Local Traffic Policies. But I don't use them a lot, so I cannot tell you how that would look like.

KR
Daniel