Single I-rule with 1000+ URI Redirect

For that many redirects, I'd HIGHLY recommend a data group list to map to-from information, and then a much smaller iRule.

Example iRule:

when HTTP_REQUEST {
    if { [class match [string tolower [HTTP::uri]] starts_with my_uri_dg] } {
        HTTP::redirect "http://[HTTP::host][class match -value [string tolower [HTTP::uri]] starts_with my_uri_dg]"
    }
}

Example (string-based) data group list:

/aboutus/contactus/index.html := /en/about/contact
/aboutyou/contactme/index.html := /en/about/contactme
/aboutfred/contactfred/index.html := /en/about/contactfred

Also notice that the left side is all lowercase, because you're evaluating a [string tolower ] match in the iRule. In this way you can manage a 1000 line data group list instead of a much larger and much more complicated iRule.