Session Persistence with more IP addresses

I think this is the solution for you:

 

https://devcentral.f5.com/s/articles/xff-universal-persistence-irule

 

Summary:

 

you should create universal persistence profile -> config it with this iRule will take the first IP in case there is multiple IPs:

 

 Name: persist_xff_uie

 To be used with UIE Persistence Profile

 Checks HTTP Request for 'X-Forwarded-For' header and if exists takes the first 'X-Forwarded-For' IP address as sets as 
 Persist identifier.
 If the 'X-Forwarded-For' header does not exist then the client IP address is set as Persist identifier.

when HTTP_REQUEST { 
    if {[HTTP::header X-Forwarded-For] != ""} then {
        persist uie [lindex [ split [lindex [HTTP::header values X-Forwarded-For] 0] "," ] 0]
    } else {
        persist uie [IP::client_addr]
    }
}

Good luck!