Selective SSL offload based on URL

Actually no, sort of. HTTP host and URI values are not visible until after SSL decryption. That said, if you're strictly talking about URI paths, then it's a hard NO. But if you're talking about host names, you could conceivably do this for TLS-based clients (clients that support the TLS protocol, which is usually anything greater than WinXP). Using an iRule to sniff the server_name extension field in a CLIENTHELLO message, you could persist to a pool and disable client side SSL offload.