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LTM Sizing for Exchange 2010
Exchange 2003 is hardly the best comparison to Exchange 2010, but when dealing with 10,000 mailboxes at your largest site a 6900 model is complete overkill even if loading all of the bells and whistles. We maintain over 600k concurrent Exchange connections mostly RPC/HTTPS in a 35 node CAS Array on a 6900, SSL Offloading, irules, etc and the the unit is bored.
I would indeed engage your local F5 rep but IMHO a 1600 pair for your small site and a 3600 pair for your large site will likely give you the performance you need.
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