Load Balancing with Predictive (member)

If an application isn't just HTTP/HTTPS, do you even need persistance profiles?  In my testing with HTTP/HTTPS applications, the connections don't stay current. In that instance one needs persistance records to send you to the same server over your session.  For this application I'm load balancing, from what I've been seeing in the Pool connections, once a connection to the application is made it seems to stay "current" the entire time the user has the appliction open.  I'm wondering if just turning off the persistance records would "fix" the problem.