Issue with F5 URL.

Complete F5 URL link:

F5's ASM module has a file size restriction on file uploads. Ensure that this is not blocking users from uploading files that are large. Here is an article with more information.

If you are using the defaul tcp profile, it has a default idle timeout of 300 seconds (5 minutes). Try increasing this value to see if it helps.

Will you be able to share the output of this command:

tmsh list /ltm virtual Name_of_Virtual_Server

?

You might have run into a "response chunking" issue. Please see HTTP Request / Response Chunking and LTM HTTP Profile Option: Response Chunking for an explanation.

And what error message was displayed in the browser?

To determine the root cause of the issue, you really need to do some packet capture at various points along the chain, but I suppose it could be hard given the size of the file being transferred.