iRule for SSL certificate based on uri

Not for URIs, no. But you can with host names. The URI is a layer 7 (ie. HTTP) function. SSL negotiation happens before layer 7, so it's generally not possible to change how SSL negotiates based on the HTTP path requested. You can switch certificates used based on host name though, using Server Name Indicator (SNI) in v11, or by using wildcard or SAN certificates.