How we can publish multiple applications on same VIP with same port & same irule?

At this point I'd recommend some logging:

when HTTP_REQUEST {    
    log local0. "Incoming host: [HTTP::host]"        
    log local0. "Incoming URI: [HTTP::uri]"
    switch [string tolower [HTTP::host]] {
        "abc.com" {            
            log local0. "Catching abc.com"
            if { [string tolower [HTTP::uri]] contains "cvapweb" } {                
                log local0. "abc.com URI contains cvapweb"
                pool abc_9090
            } else {                
                log local0. "abc.com default pool"
                pool abc_8080
            }
        }
        "xyz.com" {            
            log local0. "Catching xyz.com"
            if { [string tolower [HTTP::uri]] contains "cvapweb" } {                
                log local0. "xyz.com URI contains cvapweb"
                pool xyz_9090
            } else {                
                log local0. "xyz.com default pool"
                pool xyz_8080
            }
        }
    }
}    

Tail the LTM log and test again.

tail -f /var/log/ltm    

You may be surprised by what you find.