High Packet Drop and connection failure

Yes, it is affecting traffic whereby there are some connection going from external Host to the Virtual Server failed. Have captured the traffic and am analyzing the traffic now. But the traffic volume is huge and it is really quite difficult and takes much time. Therefore, I would like to start from the basic which is to first ensure the cisco switch as well as the LTM configuration is right.

 

 

In addition, when I show interface and I found that the cisco etherchannel side have a lot of packet drop (over 10k for 1 week), does it means there must have some kind of problem between the connection of this two unit?