F5 Maximo attachments uploading issue

First of all, check if you are using the f5-tcp-progressive profile. If not, try using that one.

Next check your ltm logs to see if there is an indication why this specific upload fails. See: BIG-IP system resets the connection during file uploading/downloading, and get the error log ''011f0016:3: http_process_state_prepend - Invalid action:0x109010 Server sends too much data...'' (f5.com)

If possible, see if the issue changes when disabling/enabling a HTTP profile to the virtual server.