equal load balancing in multi tier senario :

the external f5 vs : default tcp profiles , http profile with def settings with only x-forward addded. no one connect , no persistence (cause i have one pool member which is the vs of the internal f5) the internal F5 vs : def tcp prof , def http prof , one connect prof , and cookie persist number of connections is huge sometimes 50k connection per secon

Does removing the OneConnect profile on the internal LTM have any effect?

I havnt tried it, the problem that this is a DR site , and testing anything needs a down time.