Very Slow Application performance behind F5

Updated info:

 

 

This is not DNS related. Capture shows Ack from server almost instantly, SSL handshake is very fast. After the handshake there is 9 seconds of nothing happening before the page begins to download. Still working with support on this. One caveat is that our LTM is deployed in our DMZ VLAN and for this app the pool members are a member of another network. I don't know if this could pose an issue. The tech stated most of the time the LTM is directly connected to the same network of it's pool members. We are now taking captures near the switch levels at all connect points to see if we can identify the bottleneck. Again, if we bypass the LTM everything is fine, but of course when we bypass LTM we are also bypassing our DMZ network as well.