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Using Client and Server TCP profiles when you have users coming in over WAN connections
I think what you've suggested is the approach most people take. I'd stick to that unless you have some need not to, such as links or networks that are high latency and/or lossy/unreliable/variable. Keep in mind the far end network as well as the WAN connections themselves; if users LAN connections are wireless it'll have an impact regardless of how good/stable the VPN is.
Of course, if you want to accommodate different types of links or far-end networks you might need dedicated Virtual Servers to allow the use of different client-side profiles.
Where HTTP traffic is concerned I'd suggest it's better to tweak compression and caching settings rather than TCP ones.
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