With a default TCP profile, TMM tries 5 times over 45 seconds to establish a TCP connection. If that's not enough attempts you could increase the Maximum Syn Retransmissions" option in the TCP profile.
However, it would probably be more effective to try to capture the failure happening in a tcpdump so you can see exactly what's failing. I realize that's not easy when the virtual server is in production. However, you might be able to create a test VS with a custom SNAT pool and point a test client (or front end server) at it to isolate the traffic.
Aaron
Nimbostratus
