throughput

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Do you have AVR licensed and in provisining? would be the best

also related in this are the backends where the data reside. maybe the application which host the data has not enough performance /throughput or the application itself has not the ability to offer more bandwidth

there are thousends of possibilities. But I dont think this is related to your F5 Equipment.

since I dont know your environment/ F5 Configuration, I cant add here anymore