SSL Offloading on F5 LTM

I personally don't see why not as I have a lot of customers using non standard ports for their web applications. I am curious as to why you wouldn't want to define a standard port on the virtual server as either users will need to manually define :5555 or you will need to create an iRule to redirect all requests to port 5555. As for the server side, the BIG-IP will perform any translation required to the service port of the pool members. At this point the BIG-IP is the client using ephemeral ports connecting to a static port on your web server. As long as the web server itself is listening on 5555 you should be fine. What are some of your concerns?