Rewriting Javascript w/o APM

Thanks for the quick response, Kevin.

I do have a child stream profile assigned w/ default source & target assigned to the VS. And the iRule is exactly as you described:

when HTTP_REQUEST {
    HTTP::header remove Accept-Encoding
    STREAM::disable
}
when HTTP_RESPONSE {
    if { [HTTP::header Content-Type] contains "text" } {
        STREAM::expression {@realserver@virtualserver@}
        STREAM::enable
    }
}

I even used the STREAM_MATCHED event to ensure it executed, which it does.

The other attempt was using a rewrite profile (parent of rewrite-uri-translation) to have client "https://virtualserver/kcontent/" and server "https://realserver/kcontent". This works for the initial launch of the selected user manual (iframes & javascript), but subsequent links from the TOC (iframe) fail to generate content into the secondary iframe.

I want to avoid having to edit this profile every time the content creators add new user manuals to the site.