operation not supported irule error

It's an anomalous behavior, but you cannot have multiple redirect/respond invocations in a single event. There may be multiple conditions that are proving true. I would suggest two solutions:

 

 

1. As Nitass stated, dumping all of those URIs and URI patterns into a datagroup or two will make your code WAY easier to read and manage.

 

 

2. Set a variable at the true conditions, instead of the HTTP::respond, and have a single HTTP::respond at the end that uses the variable.