Multi-Hop cycle error when navigating to F5 VIP

Our company is beginning some testing on our F5 for future applications in which an internal application talks to the F5 first to go out an access external resources.

you mean outbound connection (server initiates connection to external resource such as internet), don't you?

if yes, what virtual server configuration are you using? is it ip forwarding virtual server?

sol7595: Overview of IP forwarding virtual servers