irules for long connection

Note that if a long server side timeout is specified through a profile, this also applies to the client side timeout I believe. I'm not sure if this applies to iRules.

If the client is closing the connection in a valid way I'm not sure it will matter anyway, the F5 will surely close the related server side connection. Even if it doesn't there's no way to ensure the same server side connection will be used for that client. It may be possible but you'll need to configure Persistence and OneConnect very carefully, ensure you're using a standard VS and test, test, test.