iRule to restrict access on combinations of URI's / source addresses

Please try the below, I assume the datagroups you referred are the IP type.

Assume you have 2 datagroups where the whitelisted IP's are present.

• If Users coming from datagroup1 send requests starting with URI "/uri1/" it will allow.
• If Users coming from datagroup2 send requests starting with URI "/uri2/" it will allow.

Below are the referenced datagroups that were called in the Irule.

ltm data-group internal datagroup1 {
    records {
        20.20.20.20/32 { }
    }
    type ip
}
ltm data-group internal datagroup2 {
    records {
        10.10.10.12/32 { }
    }
    type ip
}

Irule:

ltm rule test-jai-uri {
    when HTTP_REQUEST {
    if {([class match -- [IP::client_addr] equals datagroup1] && [HTTP::uri] starts_with "/uri1/") || ([class match -- [IP::client_addr] equals datagroup2] && [HTTP::uri] starts_with "/uri2/")}{
    log local0. "Success log"
    HTTP::respond 200 content {200 SUCCESS}
    } else {
    log local0. "Failure log"
    HTTP::respond 403 content {403 Unauthorized}
    }
    }
    }

A tip: you can test any case scenario by just using simple logging and http respond options to know if your irule is working or not. I tested in my env and it works.