Irule to bypass http profile on APM VS

Yeah or :

when HTTP_REQUEST { if {[HTTP::uri] contains "chat.phl.com"}
{
Log local0. "HTTP URI contains chat.phl.com"    
virtual /Common/VS_CHAT
}

And add this log iRule on the second VS (once without HTTP profile)

when CLIENT_ACCEPTED { log local0. "Connection on NON_HTTP VS"}

Don't forget to add ressources on the second VS (Pool and members). This VS can have any IP address. It doesn't matter because the connection comes from the first VS.

Hope this solution will works in your case. Else, enable logs on LTM and try to understand why HTTP profile meets an issue.