irule performance issue

You should be using data classes for this task. Something similar to..

when HTTP_REQUEST {
  if {[class match [HTTP::uri] equals myclass]} {
     HTTP::redirect [class match -value [HTTP::uri] equals myclass]
  }
}

Then define a string data class with your redirect requirements.

Name                  Value
/home                 http://newhome.host.com/home
/home2                http://otherhome.host.com