Irule for multiple links in the same website

Ok, now I understand. So what you probably want to do is so that the links shouldn't even contain http://abc.test.com.uk:10000/dir but rather point to https://def.test.com.uk/dir instead. In some applications it's actually possible to configure so that the application is aware that it resides behind an ADC and allows you to configure the external address.

In case that possibility doesn't exist there is always the option to let the BIG-IP rewrite the pages so that the internal URL:s is translated to the external one. This is easiest accomplished with the stream profile.

Basically what you do is to configure the profile to look for http://abc.test.com.uk:10000 and replace with https://def.test.com.uk.