irule for choosing pool and rewriting

when HTTP_REQUEST {
 set HOST [string tolower [HTTP::host]]
  set HOST [string tolower [HTTP::uri]]

   if { ($HOST eq "host.domain.tld") and ($URI eq "/example1/appname")} {
       HTTP::uri  [string map {"/example1" ""} [HTTP::uri]]
         HTTP::host [string map {"host.domain.tld" "example1_pool"} [HTTP::host]]
         pool APPNAME_POOL_example1

   }
}

You would have to run some curl commands to figure out the response from the servers and possibly make changes to the response headers.