Guidelines for pointing to one web server with many Virtual Sites

Ah, sorry to be so vague, what I mean is an Apache instance (one only) that has a number of virtual server definitions on it, basically it's a "content" server with a number of marketing websites. I was just wondering how best to configure the F5, in that should I use an iRule, or anything, or just set up a virtual server on the F5 for each instance on the web server...

 

Thanks!

 

JP