GTM with MS Unified Access Gateway and two ISPs.

Greets. I've been tasked with using our GTM/LTMs to front end MS Unified Access Gateway. We have two ISPs (data centers) and the request is active/active. Searching DevCentral and contacting support has lead me here. Has anyone else out there done this successfully and if so, could you point me in the right direction? I've considered topology, but heard it can be troublesome to support. What other active/active configuration(s) should I consider? The GTMs (one in each data center) iQuery the LTMs (one in each data center).