You mean that F5 ASM policy is in transperant mode and you still get performance and functional issues?
Have you checked the F5 ASM CPU and Memory as the learning mode may cause high cpu if there is a lot to learn and I see that the confluence causes a lot of false postives (you may also upload a qkview to ihealth and check the CPU and memory and found bugsfor the ASM from the security tab in ihealth):
https://support.f5.com/csp/article/K47045262
https://support.f5.com/csp/article/K58571155
Also do you add a lot of files on the Confluence as you may need to read:
https://support.f5.com/csp/article/K01235989