F5 getting low throughput..

Kumar - your question is very very vague. Network latency can be caused by a myriad of reasons. I'd suggest you isolate first the actual network segment where latency is experienced - the point is that, if you have a path across multiple L3 and L2 hops, latency end-to-end could be caused by any of those hops.

too little information and probably won't be solved on a forum like this. best would be to open a ticket with f5 support and let them guide you through creating some packet captures to solve this.