F5 connection reset in SSL handshake

For me it looks like the SSL handshake completes successfully, as you see application data being set.

To me the issue is with the application traffic. Is it a http application and has the Vs got a http profile assigned? Is it a custom one if so, or the default http profile? Any http iRules on this VIP?

Depending on above I might replace the http profile with the default one and remove any iRules temporarily.

If no joy then we'll need the private key to decrypt the traffic to see what's going on. Or, if you use httpfox or fiddler what is the client request being sent??

HTH,

NB