F5 | LTM | Application getting time out via LB VIP

RAQS If you can provide the configuration when both nodes are in place as well as a tcpdump we might be able to assist you further with this. I would use the following as your tcpdump when you test.

tcpdump -nni 0.0:nnp host <vs_destination_IP> -w /shared/tmp/vs_tshoot.pcap

That tcpdump will save a file called vs_tshoot.pcap to /shared/tmp/ directory for you to open up in wireshark. If you are using SNAT the tcpdump will follow the connection through SNAT and typically what happens is you can filter on the client ephemeral port because the F5 attempts to use the same ephemeral port for the SNAT connection.